HUNTINGTON’S DISEASE

KIDS-HD STUDY 

  1. Schultz JL, van der Plas E, Langbehn DR, Conrad AL, Nopoulos PC.  Age-Related Cognitive Changes as a Function of CAG Repeat in Child and Adolescent Carriers of Mutant Huntingtin.  Ann Neurol. 2021 May;89(5):1036-1040. doi: 10.1002/ana.26039. Epub 2021 Feb 22.
  2. Schultz JL, Harshman LA, Kamholz JA, Nopoulos PC.  Autonomic dysregulation as an early pathologic feature of Huntington Disease.  Auton Neurosci. 2021 Mar;231:102775. doi: 10.1016/j.autneu.2021.102775. Epub 2021 Feb 5.
  3. Tereshchenko A, van der Plas E, Mathews KD, Epping E, Conrad AL, Langbehn DR, Nopoulos P.  Developmental Trajectory of Height, Weight, and BMI in Children and Adolescents at Risk for Huntington's Disease: Effect of mHTT on Growth.  J Huntingtons Dis. 2020;9(3):245-251. doi: 10.3233/JHD-200407.
  4. Tereshchenko AV, Schultz JL, Bruss JE, Magnotta VA, Epping EA, Nopoulos PC.  Abnormal development of cerebellar-striatal circuitry in Huntington disease.  Neurology. 2020 May 5;94(18):e1908-e1915. doi: 10.1212/WNL.0000000000009364. Epub 2020 Apr 7.
  5. van der Plas E, Schubert R, Reilmann R, Nopoulos PC.  A Feasibility Study of Quantitative Motor Assessments in Children Using the Q-Motor Suite.  J Huntingtons Dis. 2019;8(3):333-338. doi: 10.3233/JHD-190353.
  6. van der Plas E, Langbehn DR, Conrad AL, Koscik TR, Tereshchenko A, Epping EA, Magnotta VA, Nopoulos PC.  Abnormal brain development in child and adolescent carriers of mutant huntingtin.  Neurology. 2019 Sep 3;93(10):e1021-e1030. doi: 10.1212/WNL.0000000000008066. Epub 2019 Aug 1.
  7. Lee JK, Conrad A, Epping E, Mathews K, Magnotta V, Dawson JD, Nopoulos P.  Effect of Trinucleotide Repeats in the Huntington's Gene on Intelligence.  EBioMedicine. 2018 May;31:47-53. doi: 10.1016/j.ebiom.2018.03.031. Epub 2018 Mar 30.
  8. Lee JK, Ding Y, Conrad AL, Cattaneo E, Epping E, Mathews K, Gonzalez-Alegre P, Cahill L, Magnotta V, Schlaggar BL, Perlmutter JS, Kim RE, Dawson JD, Nopoulos P.  Sex-specific effects of the Huntington gene on normal neurodevelopment.  J Neurosci Res. 2017 Jan 2;95(1-2):398-408. doi: 10.1002/jnr.23980.
  9. Lee JM, Ramos EM, Lee JH, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M, Ross CA, Margolis RL, Squitieri F, Orobello S, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Paulsen JS; PREDICT-HD study of the Huntington Study Group (HSG), Landwehrmeyer GB; REGISTRY study of the European Huntington's Disease Network, Myers RH; HD-MAPS Study Group, MacDonald ME, Gusella JF; COHORT study of the HSG.  CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.  Neurology. 2012 Mar 6;78(10):690-5. doi: 10.1212/WNL.0b013e318249f683. Epub 2012 Feb 8.
  10. Lee JK, Mathews K, Schlaggar B, Perlmutter J, Paulsen JS, Epping E, Burmeister L, Nopoulos P.  Measures of growth in children at risk for Huntington disease.  Neurology. 2012 Aug 14;79(7):668-74. doi: 10.1212/WNL.0b013e3182648b65. Epub 2012 Jul 18.
  11. Beglinger LJ, Prest L, Mills JA, Paulsen JS, Smith MM, Gonzalez-Alegre P, Rowe KC, Nopoulos P, Uc EY.  Clinical predictors of driving status in Huntington's disease.  Mov Disord. 2012 Aug;27(9):1146-52. doi: 10.1002/mds.25101. Epub 2012 Jun 28.
  12. Byars JA, Beglinger LJ, Moser DJ, Gonzalez-Alegre P, Nopoulos P.  Substance abuse may be a risk factor for earlier onset of Huntington disease.  J Neurol. 2012 Sep;259(9):1824-31. doi: 10.1007/s00415-012-6415-8. Epub 2012 Jan 25.
  13. Nopoulos PC, Aylward EH, Ross CA, Mills JA, Langbehn DR, Johnson HJ, Magnotta VA, Pierson RK, Beglinger LJ, Nance MA, Barker RA, Paulsen JS; PREDICT-HD Investigators and Coordinators of the Huntington Study Group.  Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment.  Brain. 2011 Jan;134(Pt 1):137-42. doi: 10.1093/brain/awq280. Epub 2010 Oct 4.
  14. Aylward E, Mills J, Liu D, Nopoulos P, Ross CA, Pierson R, Paulsen JS.  Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease.  PLoS Curr. 2011 May 11;3:RRN1235. doi: 10.1371/currents.RRN1235.
  15. O'Rourke JJ, Adams WH, Duff K, Byars J, Nopoulos P, Paulsen JS, Beglinger LJ.  Estimating premorbid functioning in huntington's disease: the relationship between disease progression and the wide range achievement test reading subtest.  Arch Clin Neuropsychol. 2011 Feb;26(1):59-66. doi: 10.1093/arclin/acq088. Epub 2010 Dec 8.
  16. Aylward EH, Nopoulos PC, Ross CA, Langbehn DR, Pierson RK, Mills JA, Johnson HJ, Magnotta VA, Juhl AR, Paulsen JS; PREDICT-HD Investigators and Coordinators of Huntington Study Group.  Longitudinal change in regional brain volumes in prodromal Huntington disease.  J Neurol Neurosurg Psychiatry. 2011 Apr;82(4):405-10. doi: 10.1136/jnnp.2010.208264. Epub 2010 Sep 30.
  17. Nopoulos P, Epping EA, Wassink T, Schlaggar BL, Perlmutter J.  Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating.  Behav Brain Funct. 2011 Oct 18;7:45. doi: 10.1186/1744-9081-7-45.
  18. Nopoulos PC, Aylward EH, Ross CA, Johnson HJ, Magnotta VA, Juhl AR, Pierson RK, Mills J, Langbehn DR, Paulsen JS; PREDICT-HD Investigators Coordinators of Huntington Study Group (HSG).  Cerebral cortex structure in prodromal Huntington disease.  Neurobiol Dis. 2010 Dec;40(3):544-54. doi: 10.1016/j.nbd.2010.07.014. Epub 2010 Aug 2.
  19. Paulsen JS, Nopoulos PC, Aylward E, Ross CA, Johnson H, Magnotta VA, Juhl A, Pierson RK, Mills J, Langbehn D, Nance M; PREDICT-HD Investigators and Coordinators of the Huntington's Study Group (HSG).  Striatal and white matter predictors of estimated diagnosis for Huntington disease.  Brain Res Bull. 2010 May 31;82(3-4):201-7. doi: 10.1016/j.brainresbull.2010.04.003. Epub 2010 Apr 10.
  20. Duff K, Beglinger LJ, O'Rourke ME, Nopoulos P, Paulson HL, Paulsen JS.  Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington's disease.  Ann Clin Psychiatry. 2008 Jan-Mar;20(1):1-3. doi: 10.1080/10401230701844802.
  21. Beglinger LJ, Nopoulos PC, Jorge RE, Langbehn DR, Mikos AE, Moser DJ, Duff K, Robinson RG, Paulsen JS.  White matter volume and cognitive dysfunction in early Huntington's disease.  Cogn Behav Neurol. 2005 Jun;18(2):102-7. doi: 10.1097/01.wnn.0000152205.79033.73.

JUVENILE-ONSET HUNTINGTON'S DISEASE

  1. Schultz JL, Nopoulos PC.  Autonomic Changes in Juvenile-Onset Huntington's Disease.  Brain Sci. 2020 Aug 26;10(9):589. doi: 10.3390/brainsci10090589.
  2. Langbehn KE, Cochran AM, van der Plas E, Conrad AL, Epping E, Martin E, Espe-Pfeifer P, Nopoulos P.  Behavioral Deficits in Juvenile Onset Huntington's Disease.  Brain Sci. 2020 Aug 11;10(8):543. doi: 10.3390/brainsci10080543.
  3. Nopoulos PC.  Special Issue: Juvenile Onset Huntington's Disease.  Brain Sci. 2020 Sep 20;10(9):652. doi: 10.3390/brainsci10090652.
  4. Tereshchenko AV, Schultz JL, Kunnath AJ, Bruss JE, Epping EA, Magnotta VA, Nopoulos PC.  Subcortical T1-Rho MRI Abnormalities in Juvenile-Onset Huntington's Disease.  Brain Sci. 2020 Aug 8;10(8):533. doi: 10.3390/brainsci10080533.
  5. Schultz JL, Moser AD, Nopoulos PC.  The Association between CAG Repeat Length and Age of Onset of Juvenile-Onset Huntington's Disease.  Brain Sci. 2020 Aug 20;10(9):575. doi: 10.3390/brainsci10090575.
  6. Horton MC, Nopoulos P, Nance M, Landwehrmyer GB, Barker RA, Squitieri F; REGISTRY Investigators of the European Huntington’s Disease Network, Burgunder JM, Quarrell O.  Assessment of the Performance of a Modified Motor Scale as Applied to Juvenile Onset Huntington's Disease.  J Huntingtons Dis. 2019;8(2):181-193. doi: 10.3233/JHD-180306.
  7. Tereshchenko A, Magnotta V, Epping E, Mathews K, Espe-Pfeifer P, Martin E, Dawson J, Duan W, Nopoulos P.  Brain structure in juvenile-onset Huntington disease.  Neurology. 2019 Apr 23;92(17):e1939-e1947. doi: 10.1212/WNL.0000000000007355. Epub 2019 Apr 10.
  8. Quarrell OWJ, Nance MA, Nopoulos P, Reilmann R, Oosterloo M, Tabrizi SJ, Furby H, Saft C, Roos RAC, Squitieri F, Landwehrmeyer GB, Burgunder JM; Juvenile Huntington Disease Working Group of the European Huntington Disease Network.  Defining pediatric huntington disease: Time to abandon the term Juvenile Huntington Disease?.  Mov Disord. 2019 Apr;34(4):584-585. doi: 10.1002/mds.27640. Epub 2019 Feb 20.
  9. Moser AD, Epping E, Espe-Pfeifer P, Martin E, Zhorne L, Mathews K, Nance M, Hudgell D, Quarrell O, Nopoulos P.  A survey-based study identifies common but unrecognized symptoms in a large series of juvenile Huntington's disease.  Neurodegener Dis Manag. 2017 Oct;7(5):307-315. doi: 10.2217/nmt-2017-0019. Epub 2017 Oct 18.
  10. Tereshchenko A, McHugh M, Lee JK, Gonzalez-Alegre P, Crane K, Dawson J, Nopoulos P.  Abnormal Weight and Body Mass Index in Children with Juvenile Huntington's Disease.  J Huntingtons Dis. 2015;4(3):231-238. doi: 10.3233/JHD-150152.
  11. Quarrell OW, Nance MA, Nopoulos P, Paulsen JS, Smith JA, Squitieri F.  Managing juvenile Huntington's disease.  Neurodegener Dis Manag. 2013 Jun 1;3(3):10.2217/nmt.13.18. doi: 10.2217/nmt.13.18.

ENROLL-HD

  1. Ogilvie AC, Nopoulos PC, Schultz JL.  Quantifying the Onset of Unintended Weight Loss in Huntington's Disease: A Retrospective Analysis of Enroll-HD.  J Huntingtons Dis. 2021 Oct 4. doi: 10.3233/JHD-210488. Online ahead of print.
  2. Schultz JL, Nopoulos PC, Gonzalez-Alegre P.  Sleep disturbances by disease type and stage in Huntington's disease.  Parkinsonism Relat Disord. 2021 Aug 21;91:13-18. doi: 10.1016/j.parkreldis.2021.08.011. Online ahead of print.
  3. Schultz JL, Saft C, Nopoulos PC.  Association of CAG Repeat Length in the Huntington Gene With Cognitive Performance in Young Adults.  Neurology. 2021 May 11;96(19):e2407-e2413. doi: 10.1212/WNL.0000000000011823. Epub 2021 Mar 10.
  4. Schultz JL, Harshman LA, Langbehn DR, Nopoulos PC.  Hypertension Is Associated With an Earlier Age of Onset of Huntington's Disease.  Mov Disord. 2020 Sep;35(9):1558-1564. doi: 10.1002/mds.28062. Epub 2020 Apr 27.
  5. Schultz JL, Nopoulos PC, Killoran A, Kamholz JA.  Statin use and delayed onset of Huntington's disease.  Mov Disord. 2019 Feb;34(2):281-285. doi: 10.1002/mds.27591. Epub 2018 Dec 21.
  6. Schultz JL, Kamholz JA, Nopoulos PC, Killoran A.  Comparing Risperidone and Olanzapine to Tetrabenazine for the Management of Chorea in Huntington Disease: An Analysis from the Enroll-HD Database.  Mov Disord Clin Pract. 2018 Nov 30;6(2):132-138. doi: 10.1002/mdc3.12706. eCollection 2019 Feb.
  7. Schultz JL, Killoran A, Nopoulos PC, Chabal CC, Moser DJ, Kamholz JA.  Evaluating depression and suicidality in tetrabenazine users with Huntington disease.  Neurology. 2018 Jul 17;91(3):e202-e207. doi: 10.1212/WNL.0000000000005817. Epub 2018 Jun 20.
  8. Schultz JL, Nopoulos PC, Gonzalez-Alegre P.  Human Immunodeficiency Virus Infection in Huntington's Disease is Associated with an Earlier Age of Symptom Onset.  J Huntingtons Dis. 2018;7(2):163-166. doi: 10.3233/JHD-180287.
  9. Schultz JL, Kamholz JA, Moser DJ, Feely SM, Paulsen JS, Nopoulos PC.  Substance abuse may hasten motor onset of Huntington disease: Evaluating the Enroll-HD database.  Neurology. 2017 Feb 28;88(9):909-915. doi: 10.1212/WNL.0000000000003661. Epub 2017 Feb 1.

PREDICT-HD

  1. Younes L, Ratnanather JT, Brown T, Aylward E, Nopoulos P, Johnson H, Magnotta VA, Paulsen JS, Margolis RL, Albin RL, Miller MI, Ross CA; PREDICT-HD Investigators and Coordinators of the Huntington Study Group.  Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.  Hum Brain Mapp. 2014 Mar;35(3):792-809. doi: 10.1002/hbm.22214. Epub 2012 Dec 20.
  2. Aylward EH, Harrington DL, Mills JA, Nopoulos PC, Ross CA, Long JD, Liu D, Westervelt HK, Paulsen JS; PREDICT-HD Investigators and Coordinators of the Huntington Study Group.  Regional atrophy associated with cognitive and motor function in prodromal Huntington disease.  J Huntingtons Dis. 2013;2(4):477-89. doi: 10.3233/JHD-130076.
  3. Aylward EH, Liu D, Nopoulos PC, Ross CA, Pierson RK, Mills JA, Long JD, Paulsen JS; PREDICT-HD Investigators and Coordinators of the Huntington Study Group.  Striatal volume contributes to the prediction of onset of Huntington disease in incident cases.  Biol Psychiatry. 2012 May 1;71(9):822-8. doi: 10.1016/j.biopsych.2011.07.030. Epub 2011 Sep 9.
  4. Carlozzi NE, Stout JC, Mills JA, Duff K, Beglinger LJ, Aylward EH, Whitlock KB, Solomon AC, Queller S, Langbehn DR, Johnson SA, Paulsen JS; Predict-Hd Investigators Of The Huntington Study Group.  Estimating premorbid IQ in the prodromal phase of a neurodegenerative disease.  Clin Neuropsychol. 2011 Jul;25(5):757-77. doi: 10.1080/13854046.2011.577811.
  5. Soneson C, Fontes M, Zhou Y, Denisov V, Paulsen JS, Kirik D, Petersén A; Huntington Study Group PREDICT-HD investigators.  Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis.  Neurobiol Dis. 2010 Dec;40(3):531-43. doi: 10.1016/j.nbd.2010.07.013. Epub 2010 Aug 2.
  6. Paulsen JS, Wang C, Duff K, Barker R, Nance M, Beglinger L, Moser D, Williams JK, Simpson S, Langbehn D, van Kammen DP; PREDICT-HD Investigators of the Huntington Study Group.  Challenges assessing clinical endpoints in early Huntington disease.  Mov Disord. 2010 Nov 15;25(15):2595-603. doi: 10.1002/mds.23337.
  7. Duff K, Paulsen J, Mills J, Beglinger LJ, Moser DJ, Smith MM, Langbehn D, Stout J, Queller S, Harrington DL; PREDICT-HD Investigators and Coordinators of the Huntington Study Group.  Mild cognitive impairment in prediagnosed Huntington disease.  Neurology. 2010 Aug 10;75(6):500-7. doi: 10.1212/WNL.0b013e3181eccfa2. Epub 2010 Jul 7.
  8. Nopoulos P, Aylward E, Ross C, Johnson H, Magnotta V, Juhl A, Pierson R, Mills J, Langbehn D, Paulsen J  Cerebral cortex structure in prodromal Huntington disease.  Neurobiol Dis. 2010;40(3):544-54.
  9. Magnotta VA, Kim J, Koscik T, Beglinger LJ, Espinso D, Langbehn D, Nopoulos P, Paulsen JS.  Diffusion Tensor Imaging in Preclinical Huntington's Disease.  Brain Imaging Behav. 2009 Mar 1;3(1):77-84. doi: 10.1007/s11682-008-9051-2.
  10. Biglan KM, Ross CA, Langbehn DR, Aylward EH, Stout JC, Queller S, Carlozzi NE, Duff K, Beglinger LJ, Paulsen JS; PREDICT-HD Investigators of the Huntington Study Group.  Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study.  Mov Disord. 2009 Sep 15;24(12):1763-72. doi: 10.1002/mds.22601.

HUNTINGTON'S DISEASE - ANIMAL MODELS

  1. Zhang C, Wu Q, Liu H, Cheng L, Hou Z, Mori S, Hua J, Ross CA, Zhang J, Nopoulos PC, Duan W.  Abnormal Brain Development in Huntington' Disease Is Recapitulated in the zQ175 Knock-In Mouse Model.  Cereb Cortex Commun. 2020;1(1):tgaa044. doi: 10.1093/texcom/tgaa044. Epub 2020 Aug 5.
  2. Lee JH, Sowada MJ, Boudreau RL, Aerts AM, Thedens DR, Nopoulos P, Davidson BL.  Rhes suppression enhances disease phenotypes in Huntington's disease mice.  J Huntingtons Dis. 2014;3(1):65-71. doi: 10.3233/JHD-140094.

HUNTINGTON'S DISEASE - REVIEWS 

  1. van der Plas E, Schultz JL, Nopoulos PC.  The Neurodevelopmental Hypothesis of Huntington's Disease.  J Huntingtons Dis. 2020;9(3):217-229. doi: 10.3233/JHD-200394.
  2. Nopoulos PC.  Huntington disease: a single-gene degenerative disorder of the striatum.  Dialogues Clin Neurosci. 2016 Mar;18(1):91-8. doi: 10.31887/DCNS.2016.18.1/pnopoulos.

MYOTONIC DYSTROPHY

  1. Miller JN, Kruger A, Moser DJ, Gutmann L, van der Plas E, Koscik TR, Cumming SA, Monckton DG, Nopoulos PC.  Cognitive Deficits, Apathy, and Hypersomnolence Represent the Core Brain Symptoms of Adult-Onset Myotonic Dystrophy Type 1.  Front Neurol. 2021 Jul 1;12:700796. doi: 10.3389/fneur.2021.700796. eCollection 2021.
  2. Langbehn KE, van der Plas E, Moser DJ, Long JD, Gutmann L, Nopoulos PC.  Cognitive function and its relationship with brain structure in myotonic dystrophy type 1.  J Neurosci Res. 2021 Jan;99(1):190-199. doi: 10.1002/jnr.24595. Epub 2020 Feb 13.
  3. van der Plas E, Koscik TR, Magnotta V, Cumming SA, Monckton D, Gutmann L, Nopoulos P.  Neurocognitive Features of Motor Premanifest Individuals With Myotonic Dystrophy Type 1.  Neurol Genet. 2021 Mar 18;7(2):e577. doi: 10.1212/NXG.0000000000000577. eCollection 2021 Apr.
  4. van der Plas E, Gutmann L, Thedens D, Shields RK, Langbehn K, Guo Z, Sonka M, Nopoulos P.  Quantitative muscle MRI as a sensitive marker of early muscle pathology in myotonic dystrophy type 1.  Muscle Nerve. 2021 Apr;63(4):553-562. doi: 10.1002/mus.27174. Epub 2021 Feb 5.
  5. Koscik TR, van der Plas E, Gutmann L, Cumming SA, Monckton DG, Magnotta V, Shields RK, Nopoulos PC.  White matter microstructure relates to motor outcomes in myotonic dystrophy type 1 independently of disease duration and genetic burden.  Sci Rep. 2021 Mar 1;11(1):4886. doi: 10.1038/s41598-021-84520-2.
  6. Johnson C, Langbehn KE, Long JD, Moser D, Cross S, Gutmann L, Nopoulos PC, van der Plas E.  Encoding of facial expressions in individuals with adult-onset myotonic dystrophy type 1.  J Clin Exp Neuropsychol. 2020 Nov;42(9):932-940. doi: 10.1080/13803395.2020.1826410. Epub 2020 Oct 7.
  7. Shields RK, Lee J, Buelow A, Petrie M, Dudley-Javoroski S, Cross S, Gutmann L, Nopoulos PC.  Myotonic dystrophy type 1 alters muscle twitch properties, spinal reflexes, and perturbation-induced trans-cortical reflexes.  Muscle Nerve. 2020 Feb;61(2):205-212. doi: 10.1002/mus.26767. Epub 2019 Dec 6.
  8. Miller JN, van der Plas E, Hamilton M, Koscik TR, Gutmann L, Cumming SA, Monckton DG, Nopoulos PC.  Variant repeats within the DMPK CTG expansion protect function in myotonic dystrophy type 1.  Neurol Genet. 2020 Aug 12;6(5):e504. doi: 10.1212/NXG.0000000000000504. eCollection 2020 Oct.
  9. Langbehn KE, Carlson-Stadler Z, van der Plas E, Hefti MM, Dawson JD, Moser DJ, Nopoulos PC.  DMPK mRNA Expression in Human Brain Tissue Throughout the Lifespan.  Neurol Genet. 2020 Dec 21;7(1):e537. doi: 10.1212/NXG.0000000000000537. eCollection 2021 Feb.
  10. van der Plas E, Hamilton MJ, Miller JN, Koscik TR, Long JD, Cumming S, Povilaikaite J, Farrugia ME, McLean J, Jampana R, Magnotta VA, Gutmann L, Monckton DG, Nopoulos PC.  Brain Structural Features of Myotonic Dystrophy Type 1 and their Relationship with CTG Repeats.  J Neuromuscul Dis. 2019;6(3):321-332. doi: 10.3233/JND-190397.
  11. Ashizawa T, Gagnon C, Groh WJ, Gutmann L, Johnson NE, Meola G, Moxley R 3rd, Pandya S, Rogers MT, Simpson E, Angeard N, Bassez G, Berggren KN, Bhakta D, Bozzali M, Broderick A, Byrne JLB, Campbell C, Cup E, Day JW, De Mattia E, Duboc D, Duong T, Eichinger K, Ekstrom AB, van Engelen B, Esparis B, Eymard B, Ferschl M, Gadalla SM, Gallais B, Goodglick T, Heatwole C, Hilbert J, Holland V, Kierkegaard M, Koopman WJ, Lane K, Maas D, Mankodi A, Mathews KD, Monckton DG, Moser D, Nazarian S, Nguyen L, Nopoulos P, Petty R, Phetteplace J, Puymirat J, Raman S, Richer L, Roma E, Sampson J, Sansone V, Schoser B, Sterling L, Statland J, Subramony SH, Tian C, Trujillo C, Tomaselli G, Turner C, Venance S, Verma A, White M, Winblad S.  Consensus-based care recommendations for adults with myotonic dystrophy type 1.  Neurol Clin Pract. 2018 Dec;8(6):507-520. doi: 10.1212/CPJ.0000000000000531.

SPINOCEREBELLAR ATAXIA

  1. Morgan OP, Slapik MB, Iannuzzelli KG, LaConte SM, Lisinski JM, Nopoulos PC, Cochran AM, Kronemer SI, Rosenthal LS, Marvel CL.  The Cerebellum and Implicit Sequencing: Evidence from Cerebellar Ataxia.  Cerebellum. 2021 Apr;20(2):222-245. doi: 10.1007/s12311-020-01206-7. Epub 2020 Oct 29.
  2. Koscik TR, Sloat L, van der Plas E, Joers JM, Deelchand DK, Lenglet C, Öz G, Nopoulos PC.  Brainstem and striatal volume changes are detectable in under 1 year and predict motor decline in spinocerebellar ataxia type 1.  Brain Commun. 2020 Dec 15;2(2):fcaa184. doi: 10.1093/braincomms/fcaa184. eCollection 2020.

PREMATURITY

  1. Benavides A, Conrad AL, Brumbaugh JE, Magnotta V, Bell EF, Nopoulos P.  Long-term outcome of brain structure in female preterm infants: possible associations of liberal versus restrictive red blood cell transfusions.  J Matern Fetal Neonatal Med. 2021 Oct;34(20):3292-3299. doi: 10.1080/14767058.2019.1683157. Epub 2019 Nov 13.
  2. Benavides A, Bell EF, Georgieff MK, Josephson CD, Stowell SR, Feldman HA, Nalbant D, Tereshchenko A, Sola-Visner M, Nopoulos P.  Sex-specific cytokine responses and neurocognitive outcome after blood transfusions in preterm infants.  Pediatr Res. 2021 Apr 28. doi: 10.1038/s41390-021-01536-0. Online ahead of print.
  3. Arthur CM, Nalbant D, Feldman HA, Saeedi BJ, Matthews J, Robinson BS, Kamili NA, Bennett A, Cress GA, Sola-Visner M, Jones RM, Zimmerman MB, Neish AS, Patel RM, Nopoulos P, Georgieff MK, Roback JD, Widness JA, Josephson CD, Stowell SR.  Anemia induces gut inflammation and injury in an animal model of preterm infants.  Transfusion. 2019 Apr;59(4):1233-1245. doi: 10.1111/trf.15254. Epub 2019 Mar 21.
  4. Benavides A, Metzger A, Tereshchenko A, Conrad A, Bell EF, Spencer J, Ross-Sheehy S, Georgieff M, Magnotta V, Nopoulos P.  Correction: Sex-specific alterations in preterm brain.  Pediatr Res. 2019 Apr;85(5):732. doi: 10.1038/s41390-019-0323-x.
  5. Benavides A, Metzger A, Tereshchenko A, Conrad A, Bell EF, Spencer J, Ross-Sheehy S, Georgieff M, Magnotta V, Nopoulos P.  Sex-specific alterations in preterm brain.  Pediatr Res. 2019 Jan;85(1):55-62. doi: 10.1038/s41390-018-0187-5. Epub 2018 Sep 19.
  6. Brumbaugh JE, Conrad AL, Lee JK, DeVolder IJ, Zimmerman MB, Magnotta VA, Axelson ED, Nopoulos PC.  Altered brain function, structure, and developmental trajectory in children born late preterm.  Pediatr Res. 2016 Aug;80(2):197-203. doi: 10.1038/pr.2016.82. Epub 2016 Apr 11.
  7. McCoy TE, Conrad AL, Richman LC, Brumbaugh JE, Magnotta VA, Bell EF, Nopoulos PC.  The relationship between brain structure and cognition in transfused preterm children at school age.  Dev Neuropsychol. 2014;39(3):226-32. doi: 10.1080/87565641.2013.874428.
  8. McCoy TE, Conrad AL, Richman LC, Nopoulos PC, Bell EF.  Memory processes in learning disability subtypes of children born preterm.  Child Neuropsychol. 2013;19(2):173-89. doi: 10.1080/09297049.2011.648922. Epub 2012 Mar 1.
  9. Carter CS, Vogel TW, Zhang Q, Seo S, Swiderski RE, Moninger TO, Cassell MD, Thedens DR, Keppler-Noreuil KM, Nopoulos P, Nishimura DY, Searby CC, Bugge K, Sheffield VC.  Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model.  Nat Med. 2012 Dec;18(12):1797-804. doi: 10.1038/nm.2996. Epub 2012 Nov 18.
  10. Nopoulos P, Conrad A, Bell E, Strauss R, Widness J, Magnotta V, Zimmerman B, Georgieff M, Lindgren S, Richman L  Long-term outcome of brain structure in premature infants: effects of liberal versus restricted transfusions.   Arch Pediatr Adolesc Med. 2011;165(5):443-50
  11. Nopoulos PC, Conrad AL, Bell EF, Strauss RG, Widness JA, Magnotta VA, Zimmerman MB, Georgieff MK, Lindgren SD, Richman LC.  Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions.  Arch Pediatr Adolesc Med. 2011 May;165(5):443-50. doi: 10.1001/archpediatrics.2010.269. Epub 2011 Jan 3.
  12. McCoy TE, Conrad AL, Richman LC, Lindgren SD, Nopoulos PC, Bell EF.  Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion.  Child Neuropsychol. 2011;17(4):347-67. doi: 10.1080/09297049.2010.544647.
  13. Erkonen GE, Hermann GM, Miller RL, Thedens DL, Nopoulos PC, Wemmie JA, Roghair RD.  Neonatal leptin administration alters regional brain volumes and blocks neonatal growth restriction-induced behavioral and cardiovascular dysfunction in male mice.  Pediatr Res. 2011 May;69(5 Pt 1):406-12. doi: 10.1203/PDR.0b013e3182110c7d.
  14. Conrad AL, Richman L, Lindgren S, Nopoulos P.  Biological and environmental predictors of behavioral sequelae in children born preterm.  Pediatrics. 2010 Jan;125(1):e83-9. doi: 10.1542/peds.2009-0634. Epub 2009 Dec 14.

CHRONIC KIDNEY DISEASE

  1. van der Plas E, Lullmann O, Hopkins L, Schultz JL, Nopoulos PC, Harshman LA.  Associations between neurofilament light-chain protein, brain structure, and chronic kidney disease.  Pediatr Res. 2021 Jul 17. doi: 10.1038/s41390-021-01649-6. Online ahead of print.
  2. Solomon MA, van der Plas E, Langbehn KE, Novak M, Schultz JL, Koscik TR, Conrad AL, Brophy PD, Furth SL, Nopoulos PC, Harshman LA.  Early pediatric chronic kidney disease is associated with brain volumetric gray matter abnormalities.  Pediatr Res. 2021 Feb;89(3):526-532. doi: 10.1038/s41390-020-01203-w. Epub 2020 Oct 17.

SEX AND GENDER DIFFERENCES

  1. Belfi AM, Conrad AL, Dawson J, Nopoulos P.  Masculinity/femininity predicts brain volumes in normal healthy children.  Dev Neuropsychol. 2014;39(1):25-36. doi: 10.1080/87565641.2013.839681.
  2. Salinas J, Mills ED, Conrad AL, Koscik T, Andreasen NC, Nopoulos P.  Sex differences in parietal lobe structure and development.  Gend Med. 2012 Feb;9(1):44-55. doi: 10.1016/j.genm.2012.01.003.
  3. Koscik T, O'Leary D, Moser DJ, Andreasen NC, Nopoulos P.  Sex differences in parietal lobe morphology: relationship to mental rotation performance.  Brain Cogn. 2009 Apr;69(3):451-9. doi: 10.1016/j.bandc.2008.09.004. Epub 2008 Nov 5.
  4. Wood JL, Heitmiller D, Andreasen NC, Nopoulos P.  Morphology of the ventral frontal cortex: relationship to femininity and social cognition.  Cereb Cortex. 2008 Mar;18(3):534-40. doi: 10.1093/cercor/bhm079. Epub 2007 Jun 14.
  5. Boes AD, Tranel D, Anderson SW, Nopoulos P.  Right anterior cingulate: a neuroanatomical correlate of aggression and defiance in boys.  Behav Neurosci. 2008 Jun;122(3):677-84. doi: 10.1037/0735-7044.122.3.677.
  6. Wood JL, Murko V, Nopoulos P.  Ventral frontal cortex in children: morphology, social cognition and femininity/masculinity.  Soc Cogn Affect Neurosci. 2008 Jun;3(2):168-76. doi: 10.1093/scan/nsn010. Epub 2008 Mar 20.
  7. Nopoulos P, Flaum M, O'Leary D, Andreasen NC.  Sexual dimorphism in the human brain: evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging.  Psychiatry Res. 2000 Feb 28;98(1):1-13. doi: 10.1016/s0925-4927(99)00044-x.
  8. Nopoulos P, Flaum M, Andreasen NC.  Sex differences in brain morphology in schizophrenia.  Am J Psychiatry. 1997 Dec;154(12):1648-54. doi: 10.1176/ajp.154.12.1648.

NEURODEVELOPMENT

  1. Boes AD, Mehta S, Rudrauf D, Van Der Plas E, Grabowski T, Adolphs R, Nopoulos P.  Changes in cortical morphology resulting from long-term amygdala damage.  Soc Cogn Affect Neurosci. 2012 Jun;7(5):588-95. doi: 10.1093/scan/nsr047. Epub 2011 Sep 6.
  2. Boes AD, Grafft AH, Joshi C, Chuang NA, Nopoulos P, Anderson SW.  Behavioral effects of congenital ventromedial prefrontal cortex malformation.  BMC Neurol. 2011 Dec 2;11:151. doi: 10.1186/1471-2377-11-151.
  3. van der Plas EA, Boes AD, Wemmie JA, Tranel D, Nopoulos P.  Amygdala volume correlates positively with fearfulness in normal healthy girls.  Soc Cogn Affect Neurosci. 2010 Dec;5(4):424-31. doi: 10.1093/scan/nsq009. Epub 2010 Feb 11.
  4. Boes AD, Calarge C, Tranel D, Anderson S, Nopoulos P  Right ventromedial prefrontal cortex volume is a neural correlate of impulse control in normal healthy boys.  Soc Cogn Affect Neurosci. 2009; 4(1):1-9.
  5. Boes AD, Bechara A, Tranel D, Anderson SW, Richman L, Nopoulos P.  Right ventromedial prefrontal cortex: a neuroanatomical correlate of impulse control in boys.  Soc Cogn Affect Neurosci. 2009 Mar;4(1):1-9. doi: 10.1093/scan/nsn035. Epub 2008 Oct 19.
  6. Davis LK, Hazlett HC, Librant AL, Nopoulos P, Sheffield VC, Piven J, Wassink TH.  Cortical enlargement in autism is associated with a functional VNTR in the monoamine oxidase A gene.  Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1145-51. doi: 10.1002/ajmg.b.30738.
  7. Boes AD, McCormick LM, Coryell WH, Nopoulos P.  Rostral anterior cingulate cortex volume correlates with depressed mood in normal healthy children.  Biol Psychiatry. 2008 Feb 15;63(4):391-7. doi: 10.1016/j.biopsych.2007.07.018. Epub 2007 Oct 3.
  8. White T, Andreasen NC, Nopoulos P.  Brain volumes and surface morphology in monozygotic twins.  Cereb Cortex. 2002 May;12(5):486-93. doi: 10.1093/cercor/12.5.486.
  9. Nopoulos P, Berg S, Castellenos FX, Delgado A, Andreasen NC, Rapoport JL.  Developmental brain anomalies in children with attention-deficit hyperactivity disorder.  J Child Neurol. 2000 Feb;15(2):102-8. doi: 10.1177/088307380001500208.
  10. Lee JC, Nopoulos PC, Tomblin JB.  Procedural and declarative memory brain systems in developmental language disorder (DLD).  Brain Lang. 2020 Jun;205:104789. doi: 10.1016/j.bandl.2020.104789. Epub 2020 Mar 30.

NEURODEVELOPMENT - ANIMAL MODELS

  1. Aerts A, DeVolder I, Weinberg SM, Thedens D, Dunnwald M, Schutte BC, Nopoulos P.  Haploinsufficiency of interferon regulatory factor 6 alters brain morphology in the mouse.  Am J Med Genet A. 2014 Mar;164A(3):655-60. doi: 10.1002/ajmg.a.36333. Epub 2013 Dec 19.
  2. Dexter BC, Rahmouni K, Cushman T, Hermann GM, Ni C, Nopoulos PC, Thedens DL, Roghair RD.  Neonatal leptin deficiency reduces frontal cortex volumes and programs adult hyperactivity in mice.  Behav Brain Res. 2014 Apr 15;263:115-21. doi: 10.1016/j.bbr.2014.01.021. Epub 2014 Jan 25.

AGE

  1. Rowe Bijanki K, Arndt S, Magnotta VA, Nopoulos P, Paradiso S, Matsui JT, Johnson HJ, Moser DJ.  Characterizing white matter health and organization in atherosclerotic vascular disease: a diffusion tensor imaging study.  Psychiatry Res. 2013 Dec 30;214(3):389-94. doi: 10.1016/j.pscychresns.2013.07.011. Epub 2013 Oct 18.
  2. Moser DJ, Boles Ponto LL, Miller IN, Schultz SK, Menda Y, Arndt S, Nopoulos PC.  Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients.  J Clin Exp Neuropsychol. 2012;34(2):220-5. doi: 10.1080/13803395.2011.630653. Epub 2011 Dec 13.

IMAGING

  1. Guo Z, Zhang H, Chen Z, van der Plas E, Gutmann L, Thedens D, Nopoulos P, Sonka M.  Fully automated 3D segmentation of MR-imaged calf muscle compartments: Neighborhood relationship enhanced fully convolutional network.  Comput Med Imaging Graph. 2021 Jan;87:101835. doi: 10.1016/j.compmedimag.2020.101835. Epub 2020 Dec 10.
  2. Morrow JM, Evans MRB, Grider T, Sinclair CDJ, Thedens D, Shah S, Yousry TA, Hanna MG, Nopoulos P, Thornton JS, Shy ME, Reilly MM.  Validation of MRC Centre MRI calf muscle fat fraction protocol as an outcome measure in CMT1A.  Neurology. 2018 Sep 18;91(12):e1125-e1129. doi: 10.1212/WNL.0000000000006214. Epub 2018 Aug 17.
  3. Luehrs RE, Newell JD Jr, Comellas AP, Hoffman EA, Warner K, Croghan A, DuBose LE, Nopoulos P, Magnotta V, Arndt S, Pierce GL, Hoth KF.  CT-Measured Lung Air-Trapping is Associated with Higher Carotid Artery Stiffness in Individuals with Chronic Obstructive Pulmonary Disease.  J Appl Physiol (1985). 2018 Oct 11;125(6):1760-6. doi: 10.1152/japplphysiol.00580.2018. Online ahead of print.
  4. Bijanki KR, Matsui JT, Mayberg HS, Magnotta VA, Arndt S, Johnson HJ, Nopoulos P, Paradiso S, McCormick LM, Fiedorowicz JG, Epping EA, Moser DJ.  Depressive symptoms related to low fractional anisotropy of white matter underlying the right ventral anterior cingulate in older adults with atherosclerotic vascular disease.  Front Hum Neurosci. 2015 Jul 15;9:408. doi: 10.3389/fnhum.2015.00408. eCollection 2015.
  5. Li W, Andreasen NC, Nopoulos P, Magnotta VA.  Automated parcellation of the brain surface generated from magnetic resonance images.  Front Neuroinform. 2013 Oct 22;7:23. doi: 10.3389/fninf.2013.00023. eCollection 2013.
  6. McCormick LM, Ziebell S, Nopoulos P, Cassell M, Andreasen NC, Brumm M.  Anterior cingulate cortex: an MRI-based parcellation method.  Neuroimage. 2006 Sep;32(3):1167-75. doi: 10.1016/j.neuroimage.2006.04.227. Epub 2006 Jul 20.
  7. Cheng P, Magnotta VA, Wu D, Nopoulos P, Moser DJ, Paulsen J, Jorge R, Andreasen NC.  Evaluation of the GTRACT diffusion tensor tractography algorithm: a validation and reliability study.  Neuroimage. 2006 Jul 1;31(3):1075-85. doi: 10.1016/j.neuroimage.2006.01.028. Epub 2006 May 2.
  8. Spinks R, Magnotta VA, Andreasen NC, Albright KC, Ziebell S, Nopoulos P, Cassell M.  Manual and automated measurement of the whole thalamus and mediodorsal nucleus using magnetic resonance imaging.  Neuroimage. 2002 Oct;17(2):631-42.
  9. Ward J, Magnotta V, Andreasen NC, Ooteman W, Nopoulos P, Pierson R.  Color enhancement of multispectral MR images: improving the visualization of subcortical structures.  J Comput Assist Tomogr. 2001 Nov-Dec;25(6):942-9. doi: 10.1097/00004728-200111000-00018.
  10. Magnotta VA, Andreasen NC, Schultz SK, Harris G, Cizadlo T, Heckel D, Nopoulos P, Flaum M.  Quantitative in vivo measurement of gyrification in the human brain: changes associated with aging.  Cereb Cortex. 1999 Mar;9(2):151-60. doi: 10.1093/cercor/9.2.151.

CLEFT LIP/PALATE

  1. Sun Z, da Fontoura CSG, Moreno M, Holton NE, Sweat M, Sweat Y, Lee MK, Arbon J, Bidlack FB, Thedens DR, Nopoulos P, Cao H, Eliason S, Weinberg SM, Martin JF, Moreno-Uribe L, Amendt BA.  FoxO6 regulates Hippo signaling and growth of the craniofacial complex.  PLoS Genet. 2018 Oct 4;14(10):e1007675. doi: 10.1371/journal.pgen.1007675. eCollection 2018 Oct.
  2. Goodwin JW, Conrad AL, Ansley T, Nopoulos P.  Arithmetical calculation and related neuropsychological skills in subjects with isolated oral clefts.  Neuropsychology. 2017 Oct;31(7):834-841. doi: 10.1037/neu0000381. Epub 2017 May 4.
  3. Conrad AL, Goodwin JW, Choi J, Block RI, Nopoulos P.  The Relationship of Exposure to Anesthesia on Outcomes in Children With Isolated Oral Clefts.  J Child Neurol. 2017 Mar;32(3):308-315. doi: 10.1177/0883073816681257. Epub 2016 Dec 20.
  4. Conrad AL, Richman L, Nopoulos P.  Reading Achievement in Boys With Non-Syndromic Cleft Palate Only: Relationship to Neuropsychological Skill and Neurocircuitry.  Dev Neuropsychol. 2015;40(7-8):395-406. doi: 10.1080/87565641.2016.1142991. Epub 2016 Mar 2.
  5. Chollet MB, DeLeon VB, Conrad AL, Nopoulos P.  Morphometric analysis of brain shape in children with nonsyndromic cleft lip and/or palate.  J Child Neurol. 2014 Dec;29(12):1616-25. doi: 10.1177/0883073813510603. Epub 2013 Dec 30.
  6. Conrad AL, McCoy TE, DeVolder I, Richman LC, Nopoulos P.  Reading in subjects with an oral cleft: speech, hearing and neuropsychological skills.  Neuropsychology. 2014 May;28(3):415-22. doi: 10.1037/neu0000024. Epub 2013 Nov 4.
  7. Adamson CL, Anderson VA, Nopoulos P, Seal ML, Da Costa AC.  Regional brain morphometric characteristics of nonsyndromic cleft lip and palate.  Dev Neurosci. 2014;36(6):490-8. doi: 10.1159/000365389. Epub 2014 Aug 23.
  8. Weinberg SM, Parsons TE, Fogel MR, Walter CP, Conrad AL, Nopoulos P.  Corpus callosum shape is altered in individuals with nonsyndromic cleft lip and palate.  Am J Med Genet A. 2013 May;161A(5):1002-7. doi: 10.1002/ajmg.a.35835. Epub 2013 Mar 26.
  9. van der Plas E, Koscik TR, Conrad AL, Moser DJ, Nopoulos P.  Social motivation in individuals with isolated cleft lip and palate.  J Clin Exp Neuropsychol. 2013;35(5):489-500. doi: 10.1080/13803395.2013.789828. Epub 2013 May 1.
  10. DeVolder I, Richman L, Conrad AL, Magnotta V, Nopoulos P.  Abnormal cerebellar structure is dependent on phenotype of isolated cleft of the lip and/or palate.  Cerebellum. 2013 Apr;12(2):236-44. doi: 10.1007/s12311-012-0418-y.
  11. van der Plas E, Caspell CJ, Aerts AM, Tsalikian E, Richman LC, Dawson JD, Nopoulos P.  Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate.  Pediatr Res. 2012 May;71(5):612-8. doi: 10.1038/pr.2012.12. Epub 2012 Feb 9.
  12. Richman LC, McCoy TE, Conrad AL, Nopoulos PC.  Neuropsychological, behavioral, and academic sequelae of cleft: early developmental, school age, and adolescent/young adult outcomes.  Cleft Palate Craniofac J. 2012 Jul;49(4):387-96. doi: 10.1597/10-237. Epub 2011 Sep 9.
  13. Conrad AL, Dailey S, Richman L, Canady J, Karnell MP, Axelson E, Nopoulos P.  Cerebellum structure differences and relationship to speech in boys and girls with nonsyndromic cleft of the lip and/or palate.  Cleft Palate Craniofac J. 2010 Sep;47(5):469-75. doi: 10.1597/08-228.
  14. van der Plas E, Conrad A, Canady J, Richman L, Nopoulos P.  Effects of unilateral clefts on brain structure.  Arch Pediatr Adolesc Med. 2010 Aug;164(8):763-8. doi: 10.1001/archpediatrics.2010.123.
  15. Nopoulos P, Boes AD, Jabines A, Conrad AL, Canady J, Richman L, Dawson JD.  Hyperactivity, impulsivity, and inattention in boys with cleft lip and palate: relationship to ventromedial prefrontal cortex morphology.  J Neurodev Disord. 2010 Dec;2(4):235-42. doi: 10.1007/s11689-010-9060-5. Epub 2010 Aug 28.
  16. Conrad AL, Richman L, Nopoulos P, Dailey S.  Neuropsychological functioning in children with non-syndromic cleft of the lip and/or palate.  Child Neuropsychol. 2009 Sep;15(5):471-84. doi: 10.1080/09297040802691120.
  17. Weinberg SM, Andreasen NC, Nopoulos P.  Three-dimensional morphometric analysis of brain shape in nonsyndromic orofacial clefting.  J Anat. 2009 Jun;214(6):926-36. doi: 10.1111/j.1469-7580.2009.01084.x.
  18. Conrad AL, Canady J, Richman L, Nopoulos P.  Incidence of neurological soft signs in children with isolated cleft of the lip or palate.  Percept Mot Skills. 2008 Feb;106(1):197-206. doi: 10.2466/pms.106.1.197-206.
  19. Nopoulos P, Canady J, Magnotta V, Langbehn D, Richman L  Abnormal Brain Structure in Children with Isolated Clefts of the Lip and/or Palate.  Arch Pediatr Adolesc Med 2007, 161 (8): 753-8.
  20. Nopoulos P, Langbehn DR, Canady J, Magnotta V, Richman L.  Abnormal brain structure in children with isolated clefts of the lip or palate.  Arch Pediatr Adolesc Med. 2007 Aug;161(8):753-8. doi: 10.1001/archpedi.161.8.753.
  21. Boes AD, Murko V, Wood JL, Langbehn DR, Canady J, Richman L, Nopoulos P.  Social function in boys with cleft lip and palate: relationship to ventral frontal cortex morphology.  Behav Brain Res. 2007 Aug 6;181(2):224-31. doi: 10.1016/j.bbr.2007.04.009. Epub 2007 Apr 22.
  22. Nopoulos P, Richman L, Andreasen NC, Murray JC, Schutte B.  Abnormal brain structure in adults with Van der Woude syndrome.  Clin Genet. 2007 Jun;71(6):511-7. doi: 10.1111/j.1399-0004.2007.00799.x.
  23. Nopoulos P, Murray J, Schutte B, Richman L  Cognitive dysfunction in adults with Van der Woude syndrome.  Genet Med 2007; 9:213-218
  24. Nopoulos P, Richman L, Andreasen N, Murray JC, Schutte B.  Cognitive dysfunction in adults with Van der Woude syndrome.  Genet Med. 2007 Apr;9(4):213-8. doi: 10.1097/gim.0b013e3180335abd.
  25. Shriver AS, Canady J, Richman L, Andreasen NC, Nopoulos P.  Structure and function of the superior temporal plane in adult males with cleft lip and palate: pathologic enlargement with no relationship to childhood hearing deficits.  J Child Psychol Psychiatry. 2006 Oct;47(10):994-1002. doi: 10.1111/j.1469-7610.2006.01679.x.
  26. Nopoulos P, Choe I, Berg S, Van Demark D, Canady J, Richman L.  Ventral frontal cortex morphology in adult males with isolated orofacial clefts: relationship to abnormalities in social function.  Cleft Palate Craniofac J. 2005 Mar;42(2):138-44. doi: 10.1597/03-112.1.
  27. Nopoulos P, Richman L, Murray J, Canady J.  Cleft palate and craniofacial conditions.  Cleft Palate Craniofac J. 2002 Jan;39(1):123-4. doi: 10.1597/1545-1569_2002_039_0123_ltte_2.0.co_2.
  28. Nopoulos P, Berg S, VanDemark D, Richman L, Canady J, Andreasen NC.  Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate.  Neuropsychologia. 2002;40(12):2178-84. doi: 10.1016/s0028-3932(02)00043-x.
  29. Nopoulos P, Berg S, Canady J, Richman L, Van Demark D, Andreasen NC.  Structural brain abnormalities in adult males with clefts of the lip and/or palate.  Genet Med. 2002 Jan-Feb;4(1):1-9. doi: 10.1097/00125817-200201000-00001.
  30. Nopoulos P, Berg S, VanDemark D, Richman L, Canady J, Andreasen NC.  Increased incidence of a midline brain anomaly in patients with nonsyndromic clefts of the lip and/or palate.  J Neuroimaging. 2001 Oct;11(4):418-24. doi: 10.1111/j.1552-6569.2001.tb00072.x.
  31. Nopoulos P, Berg S, Canady J, Richman L, Van Demark D, Andreasen NC.  Abnormal brain morphology in patients with isolated cleft lip, cleft palate, or both: a preliminary analysis.  Cleft Palate Craniofac J. 2000 Sep;37(5):441-6. doi: 10.1597/1545-1569_2000_037_0441_abmipw_2.0.co_2.

SYNDROMES

  1. Lee JC, Nopoulos PC, Bruce Tomblin J.  Abnormal subcortical components of the corticostriatal system in young adults with DLI: a combined structural MRI and DTI study.  Neuropsychologia. 2013 Sep;51(11):2154-61. doi: 10.1016/j.neuropsychologia.2013.07.011. Epub 2013 Jul 27.
  2. Albazron FM, Bruss J, Jones RM, Yock TI, Pulsifer MB, Cohen AL, Nopoulos PC, Abrams AN, Sato M, Boes AD.  Pediatric postoperative cerebellar cognitive affective syndrome follows outflow pathway lesions.  Neurology. 2019 Oct 15;93(16):e1561-e1571. doi: 10.1212/WNL.0000000000008326. Epub 2019 Sep 16.
  3. Keppler-Noreuil KM, Blumhorst C, Sapp JC, Brinckman D, Johnston J, Nopoulos PC, Biesecker LG.  Brain tissue- and region-specific abnormalities on volumetric MRI scans in 21 patients with Bardet-Biedl syndrome (BBS).  BMC Med Genet. 2011 Jul 27;12:101. doi: 10.1186/1471-2350-12-101.

SCHIZOPHRENIA

  1. Andreasen NC, Nopoulos P, Magnotta V, Pierson R, Ziebell S, Ho BC.  Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia.  Biol Psychiatry. 2011 Oct 1;70(7):672-9. doi: 10.1016/j.biopsych.2011.05.017. Epub 2011 Jul 23.
  2. Andreasen NC, Pressler M, Nopoulos P, Miller D, Ho BC.  Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs.  Biol Psychiatry. 2010 Feb 1;67(3):255-62. doi: 10.1016/j.biopsych.2009.08.040. Epub 2009 Nov 7.
  3. Nopoulos P, Magnotta VA, Mikos A, Paulson H, Andreasen NC, Paulsen JS.  Morphology of the cerebral cortex in preclinical Huntington's disease.  Am J Psychiatry. 2007 Sep;164(9):1428-34. doi: 10.1176/appi.ajp.2007.06081266.
  4. Paulsen JS, Magnotta VA, Mikos AE, Paulson HL, Penziner E, Andreasen NC, Nopoulos PC.  Brain structure in preclinical Huntington's disease.  Biol Psychiatry. 2006 Jan 1;59(1):57-63. doi: 10.1016/j.biopsych.2005.06.003. Epub 2005 Aug 22.
  5. Matsuoka Y, Nagamine M, Inagaki M, Yoshikawa E, Nakano T, Akechi T, Kobayakawa M, Hara E, Imoto S, Murakami K, Uchitomi Y.  Cavum septi pellucidi and intrusive recollections in cancer survivors.  Neurosci Res. 2006 Nov;56(3):344-6. doi: 10.1016/j.neures.2006.07.011. Epub 2006 Sep 18.
  6. Goldsberry G, O'Leary D, Hichwa R, Nopoulos P.  Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palate.  Cleft Palate Craniofac J. 2006 Nov;43(6):683-90. doi: 10.1597/05-043.
  7. Bigelow NO, Paradiso S, Adolphs R, Moser DJ, Arndt S, Heberlein A, Nopoulos P, Andreasen NC.  Perception of socially relevant stimuli in schizophrenia.  Schizophr Res. 2006 Apr;83(2-3):257-67. doi: 10.1016/j.schres.2005.12.856. Epub 2006 Feb 23.
  8. McCormick L, Decker L, Nopoulos P, Ho BC, Andreasen N.  Effects of atypical and typical neuroleptics on anterior cingulate volume in schizophrenia.  Schizophr Res. 2005 Dec 1;80(1):73-84. doi: 10.1016/j.schres.2005.06.022. Epub 2005 Sep 15.
  9. Spinks R, Nopoulos P, Ward J, Fuller R, Magnotta VA, Andreasen NC.  Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia.  Schizophr Res. 2005 Mar 1;73(2-3):229-33. doi: 10.1016/j.schres.2004.05.020.
  10. Pressler M, Nopoulos P, Ho BC, Andreasen NC.  Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposure.  Biol Psychiatry. 2005 Feb 15;57(4):394-8. doi: 10.1016/j.biopsych.2004.11.010.
  11. Gallin EK, Le Blanc SM, and Clinical Research Fellowship Program Directors  Launching a New Fellowship for Medical Students: The First Years of the Doris Duke Clinical Research Fellowship Program.  J Investig Med 2005; 53:73-81
  12. Kopelman A, Andreasen NC, Nopoulos P.  Morphology of the anterior cingulate gyrus in patients with schizophrenia: relationship to typical neuroleptic exposure.  Am J Psychiatry. 2005 Oct;162(10):1872-8. doi: 10.1176/appi.ajp.162.10.1872.
  13. Ho BC, Andreasen NC, Nopoulos P, Fuller R, Arndt S, Cadoret RJ.  Secondary prevention of schizophrenia: utility of standardized scholastic tests in early identification.  Ann Clin Psychiatry. 2005 Jan-Mar;17(1):11-8. doi: 10.1080/10401230590905272.
  14. Coryell W, Nopoulos P, Drevets W, Wilson T, Andreasen NC.  Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications.  Am J Psychiatry. 2005 Sep;162(9):1706-12. doi: 10.1176/appi.ajp.162.9.1706.
  15. Heitmiller DR, Nopoulos PC, Andreasen NC.  Changes in caudate volume after exposure to atypical neuroleptics in patients with schizophrenia may be sex-dependent.  Schizophr Res. 2004 Feb 1;66(2-3):137-42. doi: 10.1016/j.schres.2003.08.008.
  16. Crespo-Facorro B, Kim JJ, Chemerinski E, Magnotta V, Andreasen NC, Nopoulos P.  Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlates.  J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):284-94. doi: 10.1176/jnp.16.3.284.
  17. Crespo-Facorro B, Nopoulos PC, Chemerinski E, Kim JJ, Andreasen NC, Magnotta V.  Temporal pole morphology and psychopathology in males with schizophrenia.  Psychiatry Res. 2004 Dec 15;132(2):107-15. doi: 10.1016/j.pscychresns.2004.09.002.
  18. White T, Andreasen NC, Nopoulos P, Magnotta V.  Gyrification abnormalities in childhood- and adolescent-onset schizophrenia.  Biol Psychiatry. 2003 Aug 15;54(4):418-26. doi: 10.1016/s0006-3223(03)00065-9.
  19. Milev P, Ho BC, Arndt S, Nopoulos P, Andreasen NC.  Initial magnetic resonance imaging volumetric brain measurements and outcome in schizophrenia: a prospective longitudinal study with 5-year follow-up.  Biol Psychiatry. 2003 Sep 15;54(6):608-15. doi: 10.1016/s0006-3223(03)00293-2.
  20. Kim JJ, Crespo-Facorro B, Andreasen NC, O'Leary DS, Magnotta V, Nopoulos P.  Morphology of the lateral superior temporal gyrus in neuroleptic nai;ve patients with schizophrenia: relationship to symptoms.  Schizophr Res. 2003 Apr 1;60(2-3):173-81. doi: 10.1016/s0920-9964(02)00299-2.
  21. Wassink TH, Nopoulos P, Pietila J, Crowe RR, Andreasen NC.  NOTCH4 and the frontal lobe in schizophrenia.  Am J Med Genet B Neuropsychiatr Genet. 2003 Apr 1;118B(1):1-7. doi: 10.1002/ajmg.b.10071.
  22. Ho BC, Andreasen NC, Nopoulos P, Arndt S, Magnotta V, Flaum M.  Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia.  Arch Gen Psychiatry. 2003 Jun;60(6):585-94. doi: 10.1001/archpsyc.60.6.585.
  23. Fuller R, Nopoulos P, Arndt S, O'Leary D, Ho BC, Andreasen NC.  Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance.  Am J Psychiatry. 2002 Jul;159(7):1183-9. doi: 10.1176/appi.ajp.159.7.1183.
  24. Chemerinski E, Nopoulos PC, Crespo-Facorro B, Andreasen NC, Magnotta V.  Morphology of the ventral frontal cortex in schizophrenia: relationship with social dysfunction.  Biol Psychiatry. 2002 Jul 1;52(1):1-8. doi: 10.1016/s0006-3223(01)01363-4.
  25. Andreasen NC, White T, Nopoulos P  Novel methods to study brain morphology in schizophrenia.  European Psychiatry: the Journal of the Association of European Psychiatrists 2002; 17:86-87
  26. Nopoulos P, Ceilly J, Gailis E, Andreasen NC  An MRI study of midbrain morphology in patients with schizophrenia: relationship to psychosis, neuroleptics, and cerebellar neural circuitry.  Biol Psychiatry 2001; 49:13-19.
  27. Nopoulos PC, Ceilley JW, Gailis EA, Andreasen NC.  An MRI study of midbrain morphology in patients with schizophrenia: relationship to psychosis, neuroleptics, and cerebellar neural circuitry.  Biol Psychiatry. 2001 Jan 1;49(1):13-9. doi: 10.1016/s0006-3223(00)01059-3.
  28. Nopoulos P, Rideout D, Crespo-Facorro B, Andreasen NC  Sex differences in the absence of massa intermedia in patients with schizophrenia versus healthy controls.  Schizophr Res 2001; 48:177-185
  29. Nopoulos PC, Rideout D, Crespo-Facorro B, Andreasen NC.  Sex differences in the absence of massa intermedia in patients with schizophrenia versus healthy controls.  Schizophr Res. 2001 Mar 30;48(2-3):177-85. doi: 10.1016/s0920-9964(00)00067-0.
  30. Nopoulos P, Krie A, Andreasen NC.  Enlarged cavum septi pellucidi in patients with schizophrenia: clinical and cognitive correlates.  J Neuropsychiatry Clin Neurosci. 2000 Summer;12(3):344-9. doi: 10.1176/jnp.12.3.344.
  31. Ho BC, Andreasen NC, Flaum M, Nopoulos P, Miller D.  Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophrenia.  Am J Psychiatry. 2000 May;157(5):808-15. doi: 10.1176/appi.ajp.157.5.808.
  32. Ho BC, Miller D, Nopoulos P, Andreasen NC.  A comparative effectiveness study of risperidone and olanzapine in the treatment of schizophrenia.  J Clin Psychiatry. 1999 Oct;60(10):658-63. doi: 10.4088/jcp.v60n1003.
  33. Nopoulos P, Ceilly JW, Gailis EA, Andreasen NC  An MRI study of cerebellar vermis morphology in patients with schizophrenia: evidence in support of the “cognitive dysmetria” concept.  Biol Psychiatry 1999; 46:703-711
  34. Nopoulos PC, Ceilley JW, Gailis EA, Andreasen NC.  An MRI study of cerebellar vermis morphology in patients with schizophrenia: evidence in support of the cognitive dysmetria concept.  Biol Psychiatry. 1999 Sep 1;46(5):703-11. doi: 10.1016/s0006-3223(99)00093-1.
  35. Westmoreland P, Nopoulos P, Andreasen NC, Heckel D, Arndt S.   Caudate size in first episode neuroleptic naïve schizophrenic patients measured using an artificial neural network.  Biol Psychiatry 1999; 46:712-720
  36. Corson PW, Nopoulos P, Andreasen NC, Heckel D, Arndt S.  Caudate size in first-episode neuroleptic-naive schizophrenic patients measured using an artificial neural network.  Biol Psychiatry. 1999 Sep 1;46(5):712-20. doi: 10.1016/s0006-3223(99)00079-7.
  37. Wassink TH, Andreasen NC, Nopoulos P, Flaum M.  Cerebellar morphology as a predictor of symptom and psychosocial outcome in schizophrenia.  Biol Psychiatry. 1999 Jan 1;45(1):41-8. doi: 10.1016/s0006-3223(98)00175-9.
  38. Westmoreland P, Nopoulos P, Miller D, Arndt S, Andreasen NC  Change in basal ganglia volume over  years in patients with schizophrenia: typical versus atypical neuroleptics.  Am J Psychiatry 1999; 156:1200-1204
  39. Corson PW, Nopoulos P, Miller DD, Arndt S, Andreasen NC.  Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics.  Am J Psychiatry. 1999 Aug;156(8):1200-4. doi: 10.1176/ajp.156.8.1200.
  40. Andreasen NC, Nopoulos P, O'Leary DS, Miller DD, Wassink T, Flaum M.  Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms.  Biol Psychiatry. 1999 Oct 1;46(7):908-20. doi: 10.1016/s0006-3223(99)00152-3.
  41. Gold S, Arndt S, Nopoulos P, O'Leary DS, Andreasen NC.  Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia.  Am J Psychiatry. 1999 Sep;156(9):1342-8. doi: 10.1176/ajp.156.9.1342.
  42. Wassink TH, Flaum M, Nopoulos P, Andreasen NC.  Prevalence of depressive symptoms early in the course of schizophrenia.  Am J Psychiatry. 1999 Feb;156(2):315-6. doi: 10.1176/ajp.156.2.315.
  43. Nopoulos P.  The true prevalence of cavum septi pellucidi.  Pediatr Neurol. 1999 Jul;21(1):506.
  44. Tibbo P, Nopoulos P, Arndt S, Andreasen NC.  Corpus callosum shape and size in male patients with schizophrenia.  Biol Psychiatry. 1998 Sep 15;44(6):405-12. doi: 10.1016/s0006-3223(98)00096-1.
  45. Nopoulos P, Giedd N, Andreasen NC, Rapoport J  Frequency and severity of enlarged cavum septi pellucidi in childhood-onset schizophrenia.  Am J Psychiatry 1998; 155:1074-1079
  46. Nopoulos PC, Giedd JN, Andreasen NC, Rapoport JL.  Frequency and severity of enlarged cavum septi pellucidi in childhood-onset schizophrenia.  Am J Psychiatry. 1998 Aug;155(8):1074-9. doi: 10.1176/ajp.155.8.1074.
  47. Nopoulos P, Swayze V, Flaum M, Andreasen NC.  Incidence of ectopic gray matter in patients with schizophrenia and healthy control subjects studied with MRI.  J Neuropsychiatry Clin Neurosci. 1998 Summer;10(3):351-3. doi: 10.1176/jnp.10.3.351.
  48. Nopoulos P, Flaum M, Arndt S, Andreasen N.  Morphometry in schizophrenia revisited: height and its relationship to pre-morbid function.  Psychol Med. 1998 May;28(3):655-63. doi: 10.1017/s0033291797006417.
  49. Kwon JS, Shenton ME, Hirayasu Y, Salisbury DF, Fischer IA, Dickey CC, Yurgelun-Todd D, Tohen M, Kikinis R, Jolesz FA, McCarley RW.  MRI study of cavum septi pellucidi in schizophrenia, affective disorder, and schizotypal personality disorder.  Am J Psychiatry. 1998 Apr;155(4):509-15. doi: 10.1176/ajp.155.4.509.
  50. Ho BC, Nopoulos P, Flaum M, Arndt S, Andreasen NC.  Two-year outcome in first-episode schizophrenia: predictive value of symptoms for quality of life.  Am J Psychiatry. 1998 Sep;155(9):1196-201. doi: 10.1176/ajp.155.9.1196.
  51. Nopoulos P, Swayze V, Flaum M, Ehrhardt JC, Yuh WT, Andreasen NC.  Cavum septi pellucidi in normals and patients with schizophrenia as detected by magnetic resonance imaging.  Biol Psychiatry. 1997 Jun 1;41(11):1102-8. doi: 10.1016/S0006-3223(96)00209-0.
  52. Andreasen NC, O'Leary DS, Flaum M, Nopoulos P, Watkins GL, Boles Ponto LL, Hichwa RD.  Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients.  Lancet. 1997 Jun 14;349(9067):1730-4. doi: 10.1016/s0140-6736(96)08258-x.
  53. Nopoulos P, Swayze V, Andreasen NC.  Pattern of brain morphology in patients with schizophrenia and large cavum septi pellucidi.  J Neuropsychiatry Clin Neurosci. 1996 Spring;8(2):147-52. doi: 10.1176/jnp.8.2.147.
  54. Arndt S, Andreasen NC, Flaum M, Miller D, Nopoulos P.  A longitudinal study of symptom dimensions in schizophrenia. Prediction and patterns of change.  Arch Gen Psychiatry. 1995 May;52(5):352-60. doi: 10.1001/archpsyc.1995.03950170026004.
  55. Andreasen NC, Swayze V, O'Leary DS, Nopoulos P, Cizadlo T, Harris G, Arndt S, Flaum M.  Abnormalities in midline attentional circuitry in schizophrenia: evidence from magnetic resonance and positron emission tomography.  Eur Neuropsychopharmacol. 1995;5 Suppl:37-41. doi: 10.1016/0924-977x(95)00028-n.
  56. Nopoulos P, Torres I, Flaum M, Andreasen NC, Ehrhardt JC, Yuh WT.  Brain morphology in first-episode schizophrenia.  Am J Psychiatry. 1995 Dec;152(12):1721-3. doi: 10.1176/ajp.152.12.1721.
  57. Nopoulos P, Flaum M, Andreasen NC, Swayze VW  Gray matter heterotopias in schizophrenia.  Psychiatric Research: Neuroimaging 1995; 61:11-14
  58. Nopoulos PC, Flaum M, Andreasen NC, Swayze VW.  Gray matter heterotopias in schizophrenia.  Psychiatry Res. 1995 May 31;61(1):11-4. doi: 10.1016/0925-4927(95)02573-g.
  59. Andreasen NC, Arndt S, Miller D, Flaum M, Nopoulos P.  Correlational studies of the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms: an overview and update.  Psychopathology. 1995;28(1):7-17. doi: 10.1159/000284894.
  60. Andreasen NC, Nopoulos P, Schultz S, Miller D, Gupta S, Swayze V, Flaum M.  Positive and negative symptoms of schizophrenia: past, present, and future.  Acta Psychiatr Scand Suppl. 1994;384:51-9. doi: 10.1111/j.1600-0447.1994.tb05891.x.
  61. Nopoulos P, Flashman L, Flaum M, Arndt S, Andreasen N.  Stability of cognitive functioning early in the course of schizophrenia.  Schizophr Res. 1994 Dec;14(1):29-37. doi: 10.1016/0920-9964(94)90006-x.
  62. Nopoulos P, Flaum M, Miller D  Atypical neuroleptic malignant syndrome with an atypical neuroleptic.  Ann Clin Psychiatry 1990; 2:251-253

TRAINING

  1. Gallin EK, Le Blanc SM, and Clinical Research Fellowship Program Directors. Launching a New Fellowship for Medical Students: The First Years of the Doris Duke Clinical Research Fellowship Program. J Investig Med 2005; 53:73-81.